Ketamine: Uses, Interactions, Mechanism of Action - DrugBank …
WEBKetamine is a rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant.
Ketamine - StatPearls - NCBI Bookshelf
WEBJan 30, 2024 · Ketamine, through its NMDA antagonistic action, works rapidly in controlling symptoms of depression and acute suicidal ideation. Ketamine can elevate the levels of glutamate in the brain, stimulating synaptogenesis and elevated levels of brain-derived neurotrophic factor (BDNF). [11]
Ketamine - Wikipedia
WEBKetamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a treatment for depression and in pain management. [19] Ketamine is an NMDA receptor antagonist which accounts for most of …
Ketamine: What Is It, uses, treatments, effects, and more effects
WEBJul 25, 2023 · Ketamine is an anesthetic, used to induce a loss of consciousness and relieve pain. It is commonly abused for its hallucinogenic and dissociative effects and, controversially, it...
Ketamine as an antidepressant: overview of its mechanisms of action …
WEBMay 11, 2020 · The mechanism of ketamine’s antidepressant action involves the following cascade of sequential events. 41,91 –93 Ketamine has a greater affinity for NDMA receptors on γ-aminobutyric acid (GABA) interneurons, 94 which are inhibitory neurons and act to suppress excitation of downstream glutamatergic neurons. As a …
Ketamine: Dosage, Mechanism/Onset of Action, Half-Life
WEBFeb 17, 2020 · Mechanism of Action. Produces a cataleptic-like state in which the patient is dissociated from the surrounding environment by direct action on the cortex and limbic system. Ketamine is a noncompetitive NMDA receptor antagonist that blocks glutamate.
Ketamine: Uses, Dosage, Side Effects, Warnings - Drugs.com
WEBAug 27, 2024 · Interactions. What is ketamine? Ketamine is used as an anesthetic for surgery, a treatment for depression, and is a drug of abuse. Ketamine is FDA-approved as an anesthetic to put you to sleep for surgery and to help prevent pain and discomfort.
Ketamine • LITFL • CCC Pharmacology
WEBKetamine: phencyclidine derivative hypnotic and analgesic. NMDA receptor antagonist resulting in dissociative anaesthesia (profound analgesia with superficial sleep); interacts with opioid receptors - mu, delta and kappa.
Ketamine Pharmacology: An Update (Pharmacodynamics and …
WEBApr 10, 2013 · Mechanisms of Action. Ketamine neuropharmacology is complex. Ketamine essentially acts on glutamate binding sites, NMDA (N‐Methyl‐D‐Aspartate), and non‐NMDA receptors 70. The antagonism of NMDA receptor is responsible for the specific ketamine properties (amnesic and psychosensory effects, analgesia, and neuroprotection).
KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID …
WEBThe N-methyl-d-aspartate receptor (NMDA-R) antagonist, ketamine, has received a great deal of attention over the last 20 years due to the discovery that a single subanesthetic dose leads to a rapid antidepressant effect in individuals with treatment-resistant depression.