Neoantigen Vaccines; Clinical Trials, Classes, Indications, …
WEBOct 21, 2022 · Personalized neoantigen vaccines are a highly specific cancer treatment designed to induce a robust cytotoxic T-cell attack against a patient’s cancer antigens. In this study, we searched ClinicalTrials.gov for neoantigen vaccine clinical trials and systematically analyzed them, a total of 147 trials.
Neoantigens: promising targets for cancer therapy
WEBJan 6, 2023 · Recent advances in neoantigen research have accelerated the development and regulatory approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and antibody-based ...
A shared neoantigen vaccine combined with immune checkpoint …
WEBMar 27, 2024 · Therapeutic vaccines that elicit cytotoxic T cell responses targeting tumor-specific neoantigens hold promise for providing long-term clinical benefit to patients with cancer.
Personalized RNA neoantigen vaccines stimulate T cells in
WEBMay 10, 2023 · Here in a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex nanoparticles, we synthesized mRNA neoantigen vaccines in real time...
Designing neoantigen cancer vaccines, trials, and outcomes
WEBFeb 9, 2023 · Neoantigen vaccines are based on epitopes of antigenic parts of mutant proteins expressed in cancer cells. These highly immunogenic antigens may trigger the immune system to combat cancer cells. Improvements in sequencing technology and computational tools have resulted in several clinical trials of neoantigen vaccines on cancer patients.
Neoantigen vaccine: an emerging tumor immunotherapy
WEBAug 23, 2019 · Tumor vaccines targeting neoantigens mainly include nucleic acid, dendritic cell (DC)-based, tumor cell, and synthetic long peptide (SLP) vaccines. The combination with immune checkpoint inhibition therapy or radiotherapy and chemotherapy might achieve better therapeutic effects.
Neoantigen: A New Breakthrough in Tumor Immunotherapy
WEBApr 16, 2021 · Vaccines developed against neoantigens are now being used in clinical trials in various solid tumors. In this review, we summarized the latest advances in the classification of immunotherapy and the process of classification, identification and synthesis of tumor-specific neoantigens, as well as their role in current cancer immunotherapy.
Individualised neoantigen cancer vaccine therapy - The Lancet
WEBFeb 17, 2024 · Recent advancements in the understanding of immunogenic cancer epitopes and the improvement of vaccine technology rekindled interest in the concept of a so-called personalised neoantigen-based cancer vaccine.
Personalized Neoantigen Vaccines for Aggressive Cancers
WEBApr 10, 2024 · The new vaccine, TG4050, uses an engineered form of the vaccinia virus to deliver 30 personalized neoantigens (proteins unique to each patient’s tumor) into the patient to induce activation of an antitumor immune response.
Neoantigen Vaccines; Clinical Trials, Classes, Indications, …
WEBOct 21, 2022 · Personalized neoantigen vaccines are a highly specific cancer treatment designed to induce a robust cytotoxic T-cell attack against a patient's cancer antigens. In this study, we searched ClinicalTrials.gov for neoantigen vaccine clinical trials and systematically analyzed them, a total of 147 trials.
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