Kwethluk is a city in Bethel Census Area in the U.S. state of Alaska. At the 2010 census the population was 721, up from 713 in 2000. It is the bi…Kwethluk is a city in Bethel Census Area in the U.S. state of Alaska. At the 2010 census the population was 721, up from 713 in 2000. It is the birthplace of Saint Olga of Alaska. Kwethluk is located at 60°48′8″N 161°25′7″W / 60.80222°N 161.41861°W. It lies at the confluence of the Kuskokwim and Kwethluk rivers in the Yukon-Kuskokwim Delta. The constantly changing channel gives the village its name: Kwethluk is derived from the Yupik kuik, meaning "river", plus -rrluk, meaning "bad, unnatural".
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