It is well known that the biggest genetic risk factor for the autoimmune disease systemic lupus erythematosus (SLE) is major histocompatibility complex class II (MHC-II). What remains unclear is the ...

The human immune system is incredibly complex, and healthy immune systems must be able to ignore cells of the self while also rapidly responding to pathogens that are detected in the body; that ...

The seasonal influenza vaccine contains strains of viruses from distinct virus subtypes, but most people who are vaccinated will mount a strong immune response to one strain, leaving them vulnerable ...

CTEs contain multiple domains, with the simplest form comprising a protein target for a CAR T cell, for example the CD19 extracellular domain, linked to an antibody fragment that binds to a second ...

From cholera to norovirus, Giardia to hookworms, the gut is vulnerable to an impressive array of pathogens. To keep us alive in the face of this onslaught, the intestinal immune system must be ...