ascopubs.org

Assessing the Detection Power of Genome-Wide Copy Number Variation Profiles in Prostate Cancer Using Simulated Shallow Whole-Genome Sequencing Data

SNF-CLIMEDIN: A Randomized Trial of Digital Support and Intervention in Patients With Advanced Non–Small Cell Lung Cancer. A Hellenic Cooperative Oncology Group Study Shallow whole-genome sequencing ...
News Medical

Case Western cancer researchers develop algorithm to detect DNA copy-number alterations in tumors

"Now we have a background noise modeling framework that can distinguish between deviations in tumor sequencing data that arise due to inherent noise versus those that arise due to real copy-number ...
MedPage Today

In Newly Diagnosed Prostate Cancer, Detecting Variants in Homologous Recombination Repair Genes

Identification of variants influences treatment decisions. Inhibitors of the poly-ADP-ribose polymerase (PARP) system, a pathway for repairing single-stranded DNA breaks, are recommended for tumors ...
Hosted on MSN

Using exome sequencing to analyze copy number variants can increase diagnostic yield

However, ES is not the first choice for detecting copy number variants (CNVs), which are typically deletions or duplications of DNA segments. CNVs cause a significant proportion of genetic disorders.
Business Wire

Paige Expands Single AI Application to Detect Common, Rare Variants, and Precursor Lesions to Cancer Across More Than 40 Organs and Tissues

NEW YORK--(BUSINESS WIRE)--Paige, a leader in next-generation AI technology, today announced an expansion of Paige PanCancer Detect, the first AI application capable of identifying cancer across a ...
ascopubs.org

Association of high ctDNA tumor fraction (TF) and detection of clinically significant copy number (CN) losses in liquid biopsies (LBx) from patients with advanced prostate ...

Long follow-up quality of life outcomes from an investigator-initiated randomized trial of enzalutamide versus abiraterone plus prednisolone in docetaxel-untreated castration-resistant prostate cancer ...
EurekAlert!

Effectiveness of machine learning at modeling the relationship between Hi-C data and copy number variation

Copy number variation (CNV) refers to an increase or decrease in the number of copies of a DNA sequence in a genome, which can subsequently be implicit in promoting aberrant gene expression patterns ...