It has been 65 years since the scurfy mutation arose spontaneously in mice at the Oak Ridge National Laboratory in the United States, and it is 13 years since the molecular cloning of the forkhead box ...

The authors further proceed to dissociate the interactions of FoxP3 with cofactors from its DNA-binding ability. While at least two of the hypomorphic mutants show attenuated binding to the genome, as ...

The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues. More than two decades ...

To investigate how FOXP3 dE2 affects tumor immune responses, Li and colleagues examined data from patients with triple-negative breast cancer in The Cancer Genome Atlas (TCGA) and analyzed survival ...

Osaka, Japan – The immune system is tightly regulated to ensure that it only responds to actual health threats, instead of attacking our own bodies, which happens in cases of autoimmunity. Now, ...

Indiana University School of Medicine scientists have developed a new method that shifts the behavior of immunosuppressive cells in tumors, turning them from cancer protectors into tumor fighters. The ...

The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues. More than two decades ...

Scientists at the Salk Institute say they have discovered that the Foxp3 protein is essential for creating the unique chromatin architecture of regulatory T cells and, in turn, promoting their immune ...

A team of scientists from the Perelman School of Medicine at the University of Pennsylvania and Aum Biotech LLC have described the development of a novel cancer immunotherapy designed to target ...

Fine-tuning a gene centrally involved in regulating the immune system offers potential clues for future autoimmunity and cancer treatments. The immune system faces a delicate balancing act: it must be ...