As membrane fusion involves the tight association ... Thus it is not surprising that there are proteins that block SNARE accessibility. n-Sec1 is the prototypic t-SNARE protector (Fig.

SNAREs are evolutionary conserved membrane proteins involved in all fusion events of the secretory pathway and are characterized by a conserved coiled-coil segment termed the SNARE motif.

Protein clustering, membrane structure alterations ... together comprises the core SNARE complex, which mediates vesicle fusion and, in turn, neurotransmitter release within a synapse.