On the left melanoma cells (in green) can be seen surviving in the presence of cytotoxic lymphocytes (red), when they express one of these immunosuppressive proteins. If this protein is inactivated or ...

Metastasis was considered until now the most advanced stage of an oncological process; but today it appears clearly as a phenomenon that evolves on its own and starts probably much earlier than ...

The evolution of metastasis in humans is considerably less well understood than the biology of early carcinogenesis. For over a century, clinicians and scientists have been debating whether metastatic ...

Distant metastasis remains the leading cause of mortality in breast cancer, yet comprehensive population-based evaluations of metastatic site combinations and their survival implications are limited.