Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

PTIR calculates the rates at which originally monomeric proteins are transformed into aggregates at various temperatures under initial-rate settings. Utilizing SMSLS for identical conditions generates ...

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington's, Alzheimer's and Parkinson's. But to the human eye, proteins that are ...

Protein-based therapeutics have transformed treatments for numerous diseases, yet their production remains highly complex and cost-intensive [1][2],[3][4]. Downstream processing (DSP), including ...

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington’s, Alzheimer’s and Parkinson’s. But to the human eye, proteins that are ...

Mutations in or mislocalization of RNA-binding proteins, such as TDP-43 and FUS, are linked to protein aggregation in frontotemporal dementia and amyotrophic lateral sclerosis. Now, researchers led by ...

Parkinson's disease (PD) is an age-related, progressive neurodegenerative disorder. The hallmark of PD pathogenesis is the Lewy bodies (LBs) that accumulate in neurons in the substantia nigra region ...

What are the best ways to characterize proteins in solution, without matrix effects? The best methods are analytical ultracentrifugation (AUC) and flow cytometry. AUC enables measurement of ...