RAS genes constitute the most regularly mutated oncogene family in cancer. Indeed, RAS genes constituted the most regularly mutated oncogenes in the top three causes of cancer deaths in the US in 2016 ...

H-RAS, N-RAS and K-RAS GTPases promote cell-cycle progression through the RAF–MEK–ERK/MAPK, RAL and PI3K signalling pathways. Additional RAS-family members, including E-RAS, R-RAS, TC21 and RAL ...

In accordance with the features of RAS protein function essential for RAS-dependent cancer growth (membrane association, GTP binding, effector signaling), a variety of logical directions have been ...

Two biophysicists have used supercomputers to show how cell membranes control the shape, and consequently the function, of a major cancer-causing protein. Two biophysicists from Case Western Reserve ...

For many years, the Ras signaling pathway has triggered both hope and frustration in the field of cancer research. In normal health, Ras signaling is central to the regulation of intracellular ...

Many cancer medications fail to effectively target the most commonly mutated cancer genes in humans, called RAS. Now, scientists have uncovered details into how normal RAS interacts with mutated RAS ...

Researchers at the University of Illinois at Chicago have identified a new way to block the action of genetic mutations found in nearly 30 percent of all cancers. Mutations in genes for the RAS family ...

Heterogeneity among cancers plays a significant role in making the disease difficult to treat from patient to patient. Yet, there is one gene that disproportionately affects tumors and has been found ...

Class ${\rm I}_{{\rm B}}$ phosphoinositide 3-kinase γ (PI3Kγ) elicits various immunologic and cardiovascular responses; however, the molecular basis for this signal heterogeneity is unclear. PI3Kγ ...

K.W. Wood, C. Sarnecki, T.M. Roberts, J. Blenis, "ras mediates nerve growth factor receptor modulation of three signal- transducing protein kinases: MAP kinase, Raf-1 ...

For many years, the Ras signaling pathway has triggered both hope and frustration in the field of cancer research. In normal health, Ras signaling is central to the regulation of intracellular ...