The Vikings have had the 49ers’ number the past two years. One of the reasons Minnesota is 2-0 against San Francisco is the presence of defensive coordinator Brian Flores. Flores mixes things up ...

Analyzing Sunday’s San Francisco 49ers at Los Angeles Rams odds and lines, with expert NFL picks and predictions.

Rams 0-2. Series record: 49ers lead 78-69-3. Last meeting: Rams beat 49ers 21-20 in Santa Clara, Calif. on Jan. 7. Last week: 49ers lost to Minnesota 23-17; Rams lost to Arizona 41-10. 49ers offense: ...

Just moments ago, San Francisco 49ers star TE George Kittle was carted off to the locker room in that game against the Minnesota Vikings. According to Adam Schefter of ESPN, Kittle apparently ...

SANTA CLARA, Calif. (AP) — San Francisco 49ers safety Talanoa Hufanga was a full participant in practice for the first time since tearing a ligament in his knee last November and could be set to ...

The San Francisco 49ers and Los Angeles Rams play on Sunday, Sept. 22, at SoFi Stadium in a game on the NFL Week 3 schedule. Which team will win the Week 3 NFL game? The 49ers are a 7.5-point ...

The season isn't over for the 49ers despite their upset loss to the Vikings. In fact, there is a benefit to it. Here is how. Losing to the Minnesota Vikings was pitiful for the San Francisco 49ers.

The San Francisco 49ers' Week 2 clash with the Minnesota Vikings was available on TV to a huge section of the country. That is not the case with their Week 3 game with the Los Angeles Rams.

So technically, the 49ers aren't even the second-best team in the NFL during the past three seasons. That team would be Buffalo. Grant Cohn has covered the San Francisco 49ers daily since 2011.

The start of the NFL season has been littered with injuries, and the San Francisco 49ers have not escaped the outbreak. With star running back Christian McCaffrey already on injured reserve ...