Leslie Charleson, the soap-opera legend who played Monica Quartermaine on 'General Hospital' starting in the 1970s, died Sunday. She was 79.

General Hospital ’s longest recurring actor and portrayer of matriarch Monica Quartermaine, Leslie Charleson, has died at 79. Since the show’s executive producer Frank Valentini shared the news on Sunday, fans and fellow cast members have shared their reactions to the significant loss.

The fictional character Monica Quartermaine was introduced in 1976 and quickly became one of the show’s most iconic and enduring figures.

General Hospital has lost its longest-serving cast member: Leslie Charleson, who had played Dr. Monica Quartermaine since 1977, has died at the age of 79. GH executive producer Frank Valentini confirmed the news of Charleson’s passing on Instagram Sunday night. “It is with a heavy heart that I announce the passing of my dear friend …

Soap opera icon Leslie Charleson, best known as Monica Quartermaine on "General Hospital," died Sunday morning after a long illness. She was 79.

Television lost one of its most influential figures with the passing of Leslie Charleson at 79. Her portrayal of Monica Quartermaine on "General Hospital"

Colleagues are remembering the soap opera star for her "quick wit" and presence on set. She died after a long illness.

Leslie Charleson, who played popular character Dr. Monica Quartermaine for almost 50 years on “General Hospital,” has died. She was 79.

Leslie Charleson, who played cardiologist Monica Quartermaine on "General Hospital" for five decades, has died, according to the soap opera's producer. She was 79.

General Hospital’s Jason recently sided with Tracy and the Quartermaines over Sonny. Will his loyalty wind up netting him a big surprise gift?

The executive producer of "General Hospital" said the actress "was a beloved matriarch of the entire cast and crew."