The Indianapolis Colts must emerge victorious against the San Francisco 49ers, or they'll add fuel to their doubters.

The San Francisco 49ers placed linebacker Nick Martin on the Injured Reserve. He’s been out since he suffered a concussion in ...

The San Francisco 49ers don't play until Monday night this week, which makes Ricky Pearsall's injury situation all the more ...

6. San Francisco 49ers (10-4), wild card No. 2: A win Monday locks them into the field and a tie for second place in the NFC ...

Cleveland Browns All-Pro edge rusher Myles Garrett is on the doorstep of NFL history. His 21.5 sacks lead the league by a ...

San Francisco could suddenly be a dark-horse team to win the NFC West and get the conference's No. 1 overall seed.

The San Francisco 49ers defense has been surviving despite injuries, and a lot of that credit has been given to Robert Saleh.

All three members of ESPN are picking the 49ers as well. ESPN's Football Power Index simulation model has the 49ers winning ...

According to SportsLine's Inside the Lines team, Indianapolis on Monday night has much more to lose in Week 16 ...

USA Today's NFL experts make their picks for a Week 16 showdown between the Indianapolis Colts and San Francisco 49ers ...

The NFL season continues in Week 15 when the San Francisco 49ers host the Tennessee Titans on Sunday. Start time, how to ...

The last time the Colts and 49ers played was in the 2021 season, when the Colts defeated San Francisco on the road by a score ...