Protein design (or protein engineering) is a technique by which proteins with enhanced or novel functional properties are created. Proteins can be engineered by rational design, which typically ...

SARS-CoV-2 is a positive-sense single-stranded RNA virus. It is contagious in humans and is the cause of the coronavirus disease 2019 (COVID-19). A SARS-CoV-2 antibody, NT-108, exhibits potent ...

Previously, the opioid analgesic drug JCT801 was reported to induce cell death via disruption of pH homeostasis in pancreatic cancer cells. Here, the authors investigate the metabolic mechanisms ...

There is emerging interest in adaptive platform trials for inflammatory bowel disease. In this Comment, we present the results of a workshop that was convened to consider the opportunities and ...

A dynamic isotope effect in the nucleophilic substitution reaction between F − and CD 3 I Crossed-beam reactive scattering experiments of a nucleophilic substitution reaction show a dynamic ...

This Review provides an update on the role of innate and adaptive immune cells in the pathogenesis of osteoarthritis. The authors discuss emerging therapeutics that target the immune system in ...

Immunoglobulins sample vast swathes of primary sequence and conformational space to generate and select B cell clones with exquisite selectivity and affinity for specific antigens. This ...

In this Journal Club, Minoli Perera reflects on a 2005 sequencing study by Cohen et al., who discovered two common loss-of-function mutations with large effects on plasma cholesterol levels thanks ...

A deep learning-guided de novo design identifies self-assembling peptides containing non-natural amino acids capable of killing multidrug-resistant bacteria and treating mice with acute intestinal ...

The exact role FoxO3 in the regulation of cardiac regeneration remains unclear. Here, the authors show that FoxO3 negatively controls cardiomyocyte proliferation and heart regeneration in ...

Evolution is the process of heritable change in populations of organisms over multiple generations. Evolutionary biology is the study of this process, which can occur through mechanisms including ...

Simon Schlehuber and colleagues model autonomous hydrogen-powered boats as a sustainable transport solution and find potential cost benefits over longer distances. This research could inform ...