The Vikings have had the 49ers’ number the past two years. One of the reasons Minnesota is 2-0 against San Francisco is the presence of defensive coordinator Brian Flores. Flores mixes things up ...

Analyzing Sunday’s San Francisco 49ers at Los Angeles Rams odds and lines, with expert NFL picks and predictions.

The San Francisco 49ers could add a massive piece to the defense in the not-so-distant future. San Francisco already has one of the top rosters in football but it has plenty of cap space available ...

Rams 0-2. Series record: 49ers lead 78-69-3. Last meeting: Rams beat 49ers 21-20 in Santa Clara, Calif. on Jan. 7. Last week: 49ers lost to Minnesota 23-17; Rams lost to Arizona 41-10. 49ers offense: ...

As of Sept. 19, the San Francisco 49ers' odds of winning the Super Bowl (+600) make them second-best in the NFL. In their last game, the 49ers were knocked off by the Minnesota Vikings 23-17.

Just moments ago, San Francisco 49ers star TE George Kittle was carted off to the locker room in that game against the Minnesota Vikings. According to Adam Schefter of ESPN, Kittle apparently ...

SANTA CLARA, Calif. (AP) — San Francisco 49ers safety Talanoa Hufanga was a full participant in practice for the first time since tearing a ligament in his knee last November and could be set to ...

The San Francisco 49ers and Los Angeles Rams play on Sunday, Sept. 22, at SoFi Stadium in a game on the NFL Week 3 schedule. Which team will win the Week 3 NFL game? The 49ers are a 7.5-point ...

The San Francisco 49ers didn't need Christian McCaffrey, a historic day from Brock Purdy, or a defensive shutout to prove to the rest of the league that a hangover will not exist in 2024.

The San Francisco 49ers' Week 2 clash with the Minnesota Vikings was available on TV to a huge section of the country. That is not the case with their Week 3 game with the Los Angeles Rams.