If Mr. House does show up in 2296 when Season 2 is set then that would seem to settle the fan debate over which ending of Fallout: New Vegas is canon. In the game, a victory for Mr. House is one where he survives the Battle of Hoover Dam, pushes out the other factions, and remains in control of Vegas.

The 'Fallout' Season 2 trailer reveals that Justin Theroux is Robert House, plus there's a deathclaw in New Vegas.