A nested case–control (NCC) study is a variation of a case–control study in which cases and controls are drawn from the population in a fully enumerated cohort.

The nested case–control (NCC) design proposed by Thomas (1977) is an outcome-dependent cohort sampling design in epidemiology that selects controls for each case arising in a cohort from …

Jul 2, 2025 · This article provides a comprehensive overview of nested case-control studies, their features, advantages, and applications, particularly within the context of data science and technology …

In this guide, you will learn everything you need to know about the nested case-control study design, including how it works, when to use it, and how it compares to traditional case-control and cohort …

Dec 21, 2025 · This tutorial walks you through the structure, benefits, and best practices of conducting nested case-control studies in pharma and clinical trial settings.

Jun 30, 2025 · This article explores the concept, structure, and strategic sampling methods within nested case-control studies, offering guidance on how and when to apply this powerful design.

The nested case-control study The nested case-control study aims to reduce the size of the cohort, by sampling a small number of controls at random from each risk set

Design and Analysis of Nested Case-Control Studies in the Presence of a Terminal Event Abstract Various methods are available for analyzing data in which multiple outcomes, including a terminal …

Apr 5, 2014 · The nested case-control design accommodates case event times into the sampling of controls. In this design one or more controls is or are selected for each case from the risk set at the …

In large cohorts, it is often more efficient to construct a case-control study within the cohort, once a significant number of cases have emerged, to study a specific exposure not measured at baseline.