Selective IgM deficiency (SIgMD) is a rare immune disorder in which a person has no immunoglobulin M (IgM) antibodies, or too little IgM, with normal levels of IgG and IgA …

Apr 26, 2024 · This topic review discusses the normal immunophysiology of IgM, theories of pathogenesis, and the clinical features, diagnosis, and treatment of sIgMD. More general …

Individuals with selective IgM deficiency have low levels or lack immunoglobulin M (IgM) but have normal levels of IgA, and IgG. These individuals may have no illness, whereas others develop …

Patients diagnosed with isolated primary immunoglobulin M deficiency frequently exhibit recurrent infections with common microorganisms as well as a higher incidence of autoimmune and …

Jun 9, 2025 · IgM antibodies (immunoglobulins) are the first antibodies your immune system makes in response to an infection. High IgM might mean you’ve had a recent infection.

Aug 16, 2025 · Unpack the meaning of low IgM levels, its role in immune function, and the implications for your overall health and body’s defense.

Sep 15, 2025 · In this retrospective study, we analyzed a pediatric cohort with isolated IgM deficiency, irrespective of infectious history. Clinical features—including cytopenia, …

Dec 27, 2024 · Patients may be asymptomatic, with a decreased IgM level noted during the investigation of other diseases, such as malignancies or autoimmune diseases. Prolonged or …

Explore the causes of low IgM levels, including genetic and environmental factors. Understand diagnostic and treatment options for immunodeficiencies. 🦠🩺

Patients with SIGMD have low levels of immunoglobulin M (IgM) with normal IgG, IgA, and T cells (a type of immune cell). SIGMD is diagnosed in both children and adults and is one of more …