In 2002, the WHI trial triggered a black box warning on hormone therapy — almost overnight. But the warning was built on misunderstandings that took on a life of their own. Here’s what the WHI actually found: • The “increased breast-cancer risk” was small — about 1 additional case per 100 women using combined HRT for ~5 years compared to non-users. • The average participant was 63, not a woman starting HRT in her 40s or 50s. • Many already had higher baseline risk due to age, weight, and metabol

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